Manchester United take on Leicester in the first match on Friday, August 10 in the late kick off.
Jose Mourinho and his side are currently on their tour of the US where they played Club America in the early hours of Friday morning.
They face San Jose Earthquakes in the second match tomorrow night (10pm BST) as they look to build on the 1-1 draw against the Liga MX side.
However, it seems Mourinho has already settled on his back four for the visit of the Foxes despite the Red Devils having five pre-season matches still to play.
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Valencia, Smalling, Bailly and Shaw, they are probably the ones to start the season
Mourinho looks set to start with Antonio Valencia, Chris Smalling, Eric Bailly and Luke Shaw as his backline.
"Valencia, Smalling, Bailly and Shaw, they are probably the ones to start the season," Mourinho told MUTV.
The aforementioned quartet all started the game against Club America with Lee Grant making his debut in goal as David De Gea is still resting after the World Cup.
Timothy Fosu-Mensah, Axel Tuanzebe and Matteo Darmian were all given runouts in the second half as they look to impress the Portuguese.
However, Darmian looks likely to leave the club before the transfer window shuts on Thursday, August 9.
The Italian is set to be closing in on a move to Juventus having struggled to make a name for himself under Mourinho last season.