Red Devils boss Mourinho welcomes his former side to Old Trafford on Sunday afternoon (4pm), looking to avenge the 4-0 defeat he suffered in October's reverse fixture.
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Liverpool take on West Bromwich Albion earlier in the day hoping to build on their comeback victory against Stoke City, while Arsenal will try to get back to winning ways against Middlesbrough on Monday night.
Tottenham Hotspur and Everton have seemingly easy home fixtures on Saturday while Manchester City face a difficult trip to Southampton, but who will be the big winners and losers this weekend?
Scroll through the gallery above to see our predictions for each Premier League match in Gameweek 33 - do you agree?