The youngster, who scored on his first Premier League start against Norwich, also started against Watford last week.
Kyle Walker comes back in for Kieran Tripper, while Christian Eriksen, who came on as a second-half substitute against the Hornets, has been restored to the starting line-up.
Everton have made two changes, with Tom Cleverley coming in for the injured James McCarthy.
Gerard Deulofeu, who scored in the 4-3 defeat to Stoke, has dropped to the bench.
Tottenham: Lloris, Walker, Alderweireld, Vertonghen, Davies, Dier, Carroll, Lamela, Alli, Eriksen, Kane
Subs: Vorm, Rose, Trippier, Bentaleb, Chadli, Onomah, Son
Everton: Howard, Coleman, Stones, Funes Mori, Baines, Barkley, Barry, Cleverley, Lennon, Lukaku, Koné
Subs: Robles, Jagielka, Mirallas, Besic, Deulofeu Osman, Galloway