Guidetti has not scored for Celtic since 30 November and is replaced by Leigh Griffiths up front for the Hoops.
Celtic manager Ronny Deila makes two other changes to his XI that beat Ross County 1-0 last weekend.
Adam Matthews is out and is replaced by Mikael Lustig, while Stefan Johansen replaces Liam Henderson in midfield.
Guidetti's absence means Anthony Stokes returns to the side.
As for Rangers, they play their first match since having their league clash with Hearts cancelled due to snow on 16 January.
One change has been made, with Jon Daly dropping out for Ian Black.
These sides last met in April 2012, when Celtic ran out 3-0 victors in the old Scottish Premier League.
Celtic: Gordon, Lustig, Denayer, Van Dijk, Izaguirre, Brown, Bitton, Commons, Johansen, Stokes, Griffiths.
Subs: Zaluska, Matthews, Ambrose, Guidetti, Scepovic, Forrest, Henderson.
Rangers: Simonsen, Foster, McCulloch, McGregor, Wallace, Aird, Law, Black, Hutton, Smith, Miller.
Subs: Robinson, Clark, Boyd, Shiels, Templeton, Daly, Faure.