West Indies went into bat and, despite Chris Gayle only making two of three balls, have put on a big total in south London.
Evin Lewis made 176 before being forced to retire injured and taken off on a stretcher.
Captain Jason Holder made 77 while Jason Mohammed also put on 46.
Chris Woakes was the pick of England’s bowlers with three wickets but also shipped 71 runs in 10 overs.
England, who named their Ashes squad this morning, are without Alex Hales and Ben Stokes.
Stokes has been selected for the tour despite his arrest earlier this week.
Jason Roy has come into the side and will be hoping for a strong start to get England in the mix at his home ground.
England currently lead the series 2-0 but will be will pushed to make it 3-0 after West Indies' explosive start.