Facing the axe are Leader of the House of Commons Andrea Leadsom, Work and Pension Secretary Esther McVey and Transport Secretary Chris Grayling, according to the Mail on Sunday.
Number 10 are apparently furious over Ms Leadsom and Ms McVey’s repeated threats to resign over The Prime Minister’s handling of Brexit.
Ms McVey has also been accused of “losing a grip” on her department.
Those in line for a swift promotion are Home Office minister Victoria Atkins and Attorney General Geoffrey Cox.
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Tipped rising star Ms Atkins is the daughter of former Tory MP Sir Robert Atkins and trained as a barrister before entering the Commons in 2015.
She has already faced some controversy in her short spell however, having been accused of “hypocrisy” for not supporting cannabis legalisation whilst her husband’s company runs legal non-psychoactive cannabis farms.
Mr Cox, also a barrister, apparently dropped his £670,000 worth of “additional income” from his work as a QC in order to join the Cabinet.
There is even a chance Brexit Secretary Dominic Raab will replace Philip Hammond as Chancellor, according to Mail on Sunday sources.
These predictions come as Number 10 plots to keep Ms May in power until at least 2021.
In a column for the same newspaper yesterday, the Prime Minister declared the Conservatives “the natural party of the NHS”, in contrast to the widely held view that Labour are the party that invest in state services.
The Budget this week declared an extra £394million a week would go to the NHS and an increase of 3.4 percent over the next five years.
Ms May said: “This is personal for me.
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“Just like millions of people across our country, I rely on the NHS every day.
“The wonderful staff of my local NHS trust in Berkshire help me manage by diabetes so I can live a normal life and get on with doing my job.
“As Prime Minister, I am determined to do what it takes to secure our NHS for the future so it is there for all of us.”