The businesswoman took to both her Twitter and Instagram pages to name and shame the trolls responsible for posting "disgusting" message and images about her eldest child, Harvey.
The 37-year-old informed her 2.03 million followers that she would be reporting the users to police, while appealing for any information fans could give.
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The shocking material focussed primarily on 13-year-old Harvey's disabilities. He suffers from rare genetic condition Prader-Willi syndrome, autism, ADHD and blindness.
Furious Katie wrote: "Can everyone help report this sick twisted man and if you know him give me details please.
"He needs to be named and shamed, and be questioned and clearly shouldn't be roaming around with thoughts like that about a child."
The mother-of-five continued: "I've realised so many people mocking my son out of all my children they pick on the one with disability.
"There should be more done to stop this happening to people like me and others… so angry and upset."
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As well as sharing the hurtful posts, Katie also went on to forward images of those thought to be responsible.
The star retweeted messages, such as: "Can't believe Katie Price has only just realised half the internet takes the p*** out of Harvey."
In response to a tweet which read: "I can't believe Katie Price has only just realised people make these pictures about Harvey," she replied: "And you can bind your beak in."