The 56-year-old star has featured once again on the cover of the US edition of the magazine, with strap line: 'Madonna, need we say more?'
And it appears very little has to be said about the queen of pop for her fans to go wild, as they are about this interview.
Inside, the Living For Love singer revealed details about working with Kanye West. The two superstars are both used to calling the shots in any situation, so when they teamed up for her new album Rebel Heart, it seemed inevitable that sparks would fly.
She said: "It's a little bit of a bullfight, but we take turns. He knows that he's walking into a room with a person with a strong point of view, and I do, too.
"I listen to what he has to say, take it in, and he listens to what I say and takes it in. We didn't agree on everything, but he has good ideas."
In the same interview, Madonna took issue with the suggestion the music business had become easier for women over the years.
She warned: "Don't be fooled, not much has changed - certainly not for women. We still live in a very sexist society that wants to limit people.
"Since I started, I've had people giving me a hard time because they didn't think you could be sexual or have sexuality or sensuality in your work and be intelligent at the same time. For me, the fight has never ended."
Madge also had something to say about her online haters, telling them: "You can hide behind your computer or your phone and say whatever you want - you're not known.
"Could you say it to my face? Would you say it to my face? I doubt it."
Madonna appears in the May edition of Cosmopolitan magazine, which features four different covers of the star.